Michael Otto Selected Research

Panton-Valentine leukocidin

11/2016	Increased Community-Associated Infections Caused by Panton-Valentine Leukocidin-Negative MRSA, Shanghai, 2005-2014.
9/2011	Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection.
4/2011	Panton-Valentine leukocidin antibodies for the treatment of MRSA skin infections?
12/2010	Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains.
6/2010	Relative contribution of Panton-Valentine leukocidin to PMN plasma membrane permeability and lysis caused by USA300 and USA400 culture supernatants.
9/2009	A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation.
7/2009	Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury.
12/2007	Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia.

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Michael Otto Research Topics

Disease

72	Infections 10/2023 - 09/2003
16	Staphylococcal Infections 10/2023 - 01/2008
9	Sepsis (Septicemia) 01/2017 - 01/2004
7	Bacterial Infections (Bacterial Infection) 01/2018 - 12/2008
6	Inflammation (Inflammations) 01/2023 - 07/2009
6	Bacteremia 03/2022 - 07/2004
4	Abscess 01/2022 - 12/2006
4	Soft Tissue Infections 03/2016 - 07/2004
4	Staphylococcal Pneumonia 01/2016 - 12/2007
3	Pneumonia (Pneumonitis) 01/2016 - 02/2008
2	Pain (Aches) 01/2018 - 10/2010
2	Skin Diseases (Skin Disease) 11/2013 - 04/2011
2	Neoplasms (Cancer) 09/2013 - 01/2012
2	Hemolysis 04/2012 - 05/2008
1	Ventilator-Associated Pneumonia 08/2023
1	Intestinal Diseases (Diseases, Intestinal) 01/2023
1	Dysbiosis 01/2023
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2023
1	Clostridium Infections 01/2023
1	Dehydration (Water Stress) 01/2022
1	Otitis 01/2022
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2019
1	Foodborne Diseases 01/2018
1	Hyperalgesia 01/2018
1	Melanoma (Melanoma, Malignant) 01/2018
1	Staphylococcal Food Poisoning 01/2018
1	Hyperlipidemias (Hyperlipidemia) 01/2016
1	Type 2 Diabetes Mellitus (MODY) 01/2016
1	Breakthrough Infections 04/2015
1	Acute Disease 01/2015
1	Mycoses (Diseases, Fungus) 03/2014

Drug/Important Bio-Agent (IBA)

22	Anti-Bacterial Agents (Antibiotics)IBA 09/2023 - 12/2007
14	Peptides (Polypeptides)IBA 11/2017 - 09/2003
9	Phenol (Carbolic Acid)FDA Link 01/2019 - 01/2004
8	Panton-Valentine leukocidinIBA 11/2016 - 12/2007
7	CoagulaseIBA 01/2017 - 01/2004
5	Virulence Factors (Pathogenicity Factors)IBA 08/2023 - 03/2012
5	Proteins (Proteins, Gene)FDA Link 04/2023 - 01/2013
5	VaccinesIBA 12/2021 - 01/2008
5	Antimicrobial PeptidesIBA 01/2018 - 03/2005
5	staphylococcal delta toxinIBA 11/2017 - 09/2011
4	AntibodiesIBA 06/2012 - 01/2008
3	Vancomycin FDA LinkGeneric 01/2023 - 01/2014
3	Surface-Active Agents (Surfactants)IBA 11/2018 - 01/2011
3	Hemolysin Proteins (Hemolysins)IBA 01/2018 - 12/2007
3	CytokinesIBA 01/2017 - 04/2010
3	Methicillin (Metin)FDA Link 03/2016 - 02/2012
2	Amyloid (Amyloid Fibrils)IBA 10/2023 - 03/2023
2	Carrier Proteins (Binding Protein)IBA 02/2015 - 10/2012
2	AntigensIBA 11/2013 - 01/2008
1	Bacterial Proteins (Bacterial Protein)IBA 10/2023
1	Nucleic AcidsIBA 10/2023
1	Bacteriocins (Lantibiotics)IBA 07/2023
1	Levofloxacin (Levaquin)FDA Link 01/2023
1	Sorbitol (Yal)FDA Link 01/2023
1	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2022
1	CeramidesIBA 01/2022
1	Early Growth Response Protein 1IBA 01/2022
1	staphylococcal enterotoxin BIBA 01/2021
1	InflammasomesIBA 01/2020
1	DNA (Deoxyribonucleic Acid)IBA 01/2019
1	Histones (Histone)IBA 01/2019
1	Leukocidins (Leukocidin)IBA 01/2018
1	QX-314IBA 01/2018
1	Adenosine Monophosphate (AMP)IBA 01/2018
1	Analgesics (Analgesic Drugs)IBA 01/2018
1	CationsIBA 01/2018
1	EmeticsIBA 01/2018
1	Enterotoxins (Enterotoxin)IBA 01/2018
1	Ibuprofen (Motrin)FDA LinkGeneric 01/2018
1	Lidocaine (Xylocaine)FDA LinkGeneric 01/2018
1	Sodium Channel BlockersIBA 01/2018
1	Interleukin-17 (Interleukin 17)IBA 11/2017
1	AlarminsIBA 11/2017
1	Guanosine TetraphosphateIBA 10/2016
1	GTP-Binding Proteins (G-Protein)IBA 01/2016
1	Toll-Like Receptor 2IBA 01/2016
1	Lipoproteins (Lipoprotein)IBA 01/2016
1	Glucose (Dextrose)FDA LinkGeneric 01/2016
1	Membrane Proteins (Integral Membrane Proteins)IBA 05/2015
1	Investigational DrugsIBA 05/2015
1	Fibronectins (Fibronectin)IBA 02/2015
1	FibrinIBA 02/2015
1	Fibrinogen (Factor I)FDA Link 02/2015
1	Nerve Growth Factor (NGF)IBA 10/2014
1	Cystine (L-Cystine)IBA 10/2014
1	savirinIBA 06/2014

Therapy/Procedure

13	Therapeutics 02/2023 - 01/2012
10	Catheters 01/2023 - 09/2007
2	Injections 03/2014 - 01/2012
2	Palliative Care (Palliative Therapy) 09/2013 - 01/2012
2	Immunotherapy 07/2010 - 01/2008
1	Artificial Respiration (Mechanical Ventilation) 08/2023
1	Oral Administration 11/2021
1	Intravenous Injections 01/2018
1	Investigational Therapies (Experimental Therapy) 05/2015
1	Antibiotic Prophylaxis 04/2015
1	Arthroplasty 04/2015
1	Operative Surgical Procedures 04/2015
1	Debridement 03/2014